All Rights Reserved. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. Applies only to oral form of both agents. Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Avoid or Use Alternate Drug. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Applies only to oral form of both agents. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Drug Des Devel Ther; 5: 5160. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. This document does not contain all possible drug interactions. Each mL contains 20 mg of elemental . iron sucrose decreases levels of deferiprone by enhancing GI absorption. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. Applies only to oral form of both agents. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. The primary endpoint was the proportion of patients with . Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Parenteral Iron Replacement For Iron Deficiency Anemia Calculator, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Clinical use of the total dose intravenous infusion of iron dextran, When is high-dose intravenous iron repletion needed? Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Ferrlecit may also be administered undiluted as a slow intravenous injection (at a rate of up to 12.5 mg/min) per dialysis session. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. 2012;2(4):288-335. Applies only to oral form of both agents. The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Your doctor will do laboratory tests to monitor your response. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Fatal reactions have also occurred in situations where the test dose was tolerated. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). To view formulary information first create a list of plans. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Assessing new treatment options. Applies only to oral form of both agents. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. 1 ,*. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Use Caution/Monitor. elemental iron (mg/ml) in the product being used: Where C= Recommended starting dose 1 Aranesp is dosed at 2.25 mcg/kg SC QW or 500 SC Q3W 1 (SC = subcutaneous) Before initiating 1: Evaluate iron status; administer supplemental iron therapy as needed Correct or eliminate other causes of anemia Initiate 1: Only when Hb < 10 g/dL Read our. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Canada residents can call a provincial poison control center. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Use Caution/Monitor. Applies only to oral form of both agents. Comparable efficacy to that of IV iron sucrose. iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Applies only to oral form of both agents. View the formulary and any restrictions for each plan. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. The dosage of Venofer is expressed in mg of elemental iron. Use Caution/Monitor. commonly, these are "preferred" (on formulary) brand drugs. Compare formulary status to other drugs in the same class. Minor/Significance Unknown. Do Not Copy, Distribute or otherwise Disseminate without express permission. Applies only to oral form of both agents. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. If you log out, you will be required to enter your username and password the next time you visit. Applies only to oral form of both agents. Applies only to oral form of both agents. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. 1970; 100(7):301-3. Intravenous iron sucrose: establishing a safe dose. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Applies only to oral form of both agents. If either is present, do not use the liquid. J Lab Clin Med; 111(5):566-70. sodium bicarbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Use (s): Iron deficiency anemia in patients with chronic kidney disease (CKD) rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. This health tool computes the iron deficit based on patient parameters and the Ganzoni formula. . Do not administer Venofer to patients with evidence of iron overload. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Use Caution/Monitor. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin, Do not mix with other medications or add to parenteral nutrition solutions for IV infusion, Do not dilute to concentrations below 1 mg/mL, Add dose to 0.9% NaCl infusion bags (PVC or non-PVC); final concentrations range is 1-2 mg of elemental iron/mL, Visually inspect for particulate matter and discoloration prior to infusion, Stable for 7 days at controlled room temperature (25C). however iron sucrose requires multiple small intermittent doses over days to weeks. Use Caution/Monitor. Interaction only with oral iron administration. Deferasirox chelates iron. Use Caution/Monitor. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Your doctor will do laboratory tests to monitor your response. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Applies only to oral form of both agents. Applies only to oral form of both agents. iron sucrose decreases levels of tetracycline by inhibition of GI absorption. The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. World J Gastroenterol; 16(22): 27202725. Each mL contains 20 mg of elemental iron. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Applies only to oral form of both agents. May increase risk of hypotension. Steps on how to print your input & results: 1. ONE DOSE. Applies only to oral form of both agents. It can be expressed in mg per ml. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. ]Venofer treatment may be repeated if iron deficiency reoccurs. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. May increase risk of hypotension. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. provider for the most current information. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Use Caution/Monitor. Ren Fail. Dose. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Ferumoxytol [ Feraheme ] Elemental iron: 510 mg/17 mL (17 mL) 30 mg/mL [package insert] - Boxed warning REVIEW INSERT. Minor/Significance Unknown. Monitor Closely (1)omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. VenAccess is a trademark of Vifor (International) Inc. Switzerland. iron sucrose decreases levels of manganese by inhibition of GI absorption. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. For liquid medications, also enter the value of the Medicine Concentration and choose . Applies only to oral form of both agents. vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Hanson DB, Hendeles L. Guide to total dose intravenous iron dextran therapy. DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. UpToDate. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Avoid or Use Alternate Drug. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg]. Interaction only with oral iron administration. Avoid or Use Alternate Drug. Interaction only with oral iron administration. Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Applies only to oral form of both agents. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. 2. Administer Venofer only intravenously by slow injection or by infusion. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. Slow or stop the infusion if adverse reactions occur. Venofer treatment may be repeated if necessary. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Applies only to oral form of both agents. You may need extra iron because of blood loss during kidney dialysis. iron sucrose increases levels of calcium citrate by enhancing GI absorption. Monitor Closely (1)iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. Avoid or Use Alternate Drug. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Have resuscitation equipment and personnel trained in the detection and treatment of anaphylactic-type reactions readily available during INFeD administration. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. . Contact the applicable plan Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Minor (1)iron sucrose, captopril. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Human studies not conducted. Applies only to oral form of both agents. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Applies only to oral form of both agents. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Baloxavir may bind to polyvalent cations resulting in decreased absorption. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Last updated 28/06/2018 Enter values here and press 'Calculate'. Official Journal of the International Society of Nephrology. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. 1970;100(7):301303. Applies only to oral form of both agents. Medically reviewed by Drugs.com. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. The iron formulation choice remains for the clinician to make. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Applies only to oral form of both agents. There are physiological variation in iron reserves such as the decrease during menstruation period. Applies only to oral form of both agents. Observed Hb = the patients current hemoglobin in g/dl. The recipient will receive more details and instructions to access this offer. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. This topic . Written by ASHP. * Adapted from the KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. We'll do this entirely for free, as long as the calculator has applications for women's health. Deferoxamine chelates iron. Interaction only with oral iron administration. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Iron sucrose: 20 mg/mL. All Rights Reserved. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Administer on 5 different occasions over a 14 day period. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. Applies only to oral form of both agents. Iron sucrose: 20 mg/mL. UpToDate. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Fatal reactions have followed the test dose of iron dextran injection. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. Otherwise, call a poison control center right away. Manage and view all your plans together even plans in different states. Reference www.medicines.org.uk Background Max Dose. iron sucrose, benazepril. Use Caution/Monitor. Minor/Significance Unknown. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Applies only to oral form of both agents. LBW = Lean body weight in kg. Use Caution/Monitor. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. Applies only to oral form of both agents. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) trientine, iron sucrose. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).]
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