My understanding from my vet and from what Ive read is that in horses theres been a lot of success in spacing out the dosing, but not as much success in lowering the dose amount. Yamaoka K, Saharinen P, Pesu M, et al. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. Successful treatment of atopic dermatitis with the JAK1 inhibitor oclacitinib. Gonzales AJ, Bowman JW, Fici GJ, et al. The Quick Fix For Dog Allergies - Dogs Naturally I spend $150 a month on my horse on apoquel. Most recently, it was suggested that the treatment strategy for canine atopic dermatitis might need to be adjusted. However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Apoquel is not FDA approved to use twice daily longer than 14 days. Providing Horses Relief During Allergy Season - The Horse This is a new treatment option, and currently the tablets are not FDA approved for horses, only dogs. Frank RK, Galvan BA, Schoell AR, et al. 12. 28. Do not use in breeding, pregnant, or lactating dogs. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. The recommended dosage of Apoquel 3.6mg tablets is 0.18 to 0.27 milligrams per pound of body weight. On the topic of simple and economical allergy management, a readily accessible ingredient that helps many horses is flaxseed. actually treats degenerative joint disease (DJD), not just its clinical signs. The biggest disadvantages are the cost, the need to acclimate the horse to having the device placed in his or her nostril, poor tolerance by some horses who dislike the device, and the uncertainty about how long your horse will be able to go without repeating the treatment. Vet J 2016;207:29-37. Gonzales AJ, Humphrey WR, Messamore JE, et al. Each dosage is sold per tablet, in 20 count, or 100 count bottles. 17. These and other kinase-inhibiting drugs sometimes work very well to stop the itching. A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. My Docs are among the first in the country to use this drug on itchy and wheezy horses. Vet Dermatol 2016;27(Suppl 1):100 (abstract). Specifically, studies in cats have used the following dosage: Initially, doses ranging from 0.4 to 1.2 mg/kg body weight, twice daily, for 24-28 days. Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. According to the manufacturer's dosage chart, a large breed weighing between 130 and 175lbs should take two Apoquel 16mg daily. Look for a supplement with at least 1,500mg of DHA per serving. The results are problematic. Most commonly, immunotherapy involves injecting gradually increasing doses of a specific allergen subcutaneously (just under the skin), explains White. 14. Some dogs exhibit increased pruritus when the dosage is reduced to once daily. For years, glucocorticoids and cyclosporine have been used for the symptomatic management of atopic dermatitis, including the associated pruritus. 3. Banovic F, Tarigo J, Gordon H, et al. 1,2 The #1 prescribed medicine for allergic itch in dogs. She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. Loft K, Simon B. Apoquel for horses - Horse Care - Chronicle Forums Posted by Lucile Vigouroux | May 4, 2022 | Article, Diseases and Conditions, Farm and Barn, Hives & Skin Allergies, Horse Care, Medications, Nutrition, Seasonal Care, Skin Problems. Option 4 is an oral tablet called Apoquel. The onset of efficacy for oclacitinib is up to 1 week, but Little et al found that after 4 weeks of treatment, both drugs demonstrated comparable control of clinical signs. The dose of Apoquel tablets is 0.18 to 0.27 mg/lb of body weight. I am not saying it is a cure all, but that and some generic Zyrtec make my mare a whole lot more comfortable. More severe ones, however, can truly take a toll on your horses health and make him miserable. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. Simple strategies for dust reduction include removing the horses from the stalls when mucking out and blowing the aisle or ditching the leaf blower altogether, Fultz says. The recommended dose of Apoquel for dogs is 0.18 to 0.27 mg per pound of body weight. Since oclacitinib is a rather weak anti-inflammatory drug, it was suggested that remission of active moderate to severe atopic dermatitis be induced with a course of a broad inflammation-targeting drug, such as a short-acting glucocorticoid, until clinical signs become mild. Dexamethasone: EZ Dose Micro Transdermal Gel, Dexamethasone: Twist-a-Dose Transdermal Gel, Discussion Guide for Pet Owners and Veterinarians, Medication Information for Pet and Horse Owners. Before your vet administers immunotherapy, though, you must identify your horses respiratory and skin allergies. So lets review why allergies happen, how they affect your horses body, and how to treat themor, better yet, how to avoid them altogether. It's touted as being "a fast-acting and safe treatment for the control of acute and chronic canine pruritus." Pruritus means itching. Oclacitinib is well tolerated and, compared with classic allergy medications such as glucocorticoids and cyclosporine, equally effective in controlling pruritus. Cyclosporine, which is approved for the treatment of canine atopic dermatitis, has an onset of efficacy of up to 4 weeks. The powerful network of cells and antibodies known as the immune system can recognize dangerous invaders and disarm them before they hurt the host. Apoquel for Dogs Dosing By Weight Chart - Bestie Paws Panteri A, Strehlau G, Helbig R, et al. If the patient remains stable and other controlling measures-such as allergen avoidance, allergen immunotherapy, and preventive topical therapyhave been implemented, the use of oclacitinib can be limited to flare control.16, Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats.17-20 shutterstock.com/Thrithot, Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats.17-20. Table of Contents hide Apoquel dosage for dogs chart Apoquel for Dogs Reviews: Does It Really Work? I had a cat on it years ago and it was $$$$ but it was the only thing that worked for her. 25. When your dog is itchy, you get desperate to make him feel more comfortable. This product is top-dressed onto the feed and helps horses with equine asthma, including heaves in older horses and inflammatory airway disease in young, athletic horses.". However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. There are a few medication protocols for horses with Equine Asthma. Oclacitinib: Treating Pruritus and Beyond - Today's Veterinary Practice Six adult horses with a mean weight of 528 kg were . Is it possible to cure an allergy? Preventing bites is key, because itching-inflicted injury to hair follicles and skin can take months to heal. We have been using an inflatable fleece e-collar on her . not random, very relevant and helpful! Adding an update here in case its helpful for others. The Vet had put her on Apoquel as an initial dose for 10 days tapering off. Rosenkrantz WS, Bourgeois AS. Apoquel (Oclacitinib) - rrvp.com Now divide the 10,000 mg by the 500 mg in the concentration. Option 3 is using a nebulizer with dexamethasone and/or other drugs. It is important to address that the use of oclacitinib in cats is off-label, and owners should be informed before using oclacitinib in this species. She still has her mane this year- which is good! 19. As the only FDA-approved equine PSGAG (polysulfated glycosaminoglycan) for degenerative joint disease (DJD) in horses, Adequan i.m. Oral . 20. Designed by Elegant Themes | Powered by WordPress, You need to be logged in to fill out this form. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Like other medications in its class, it may also be used off . Since oclacitinib has been shown to be comparable to prednisolone, oclacitinib can be a good alternative to prednisolone when combined with cyclosporine for initial treatment. 6. Veterinarians dose Apoquel at 0.18-0.27mg per pound of bodyweight. But you're making a deal with the devil when you use these . Everything on Apoquel: The Popular Allergy Medicine for Dogs Discount Prices on Pet Supplies, Nexgard, Bravecto, Trifexis, Simparica TRIO, Apoquel, and more. These molecules are responsible for the appearance of clinical signs commonly associated with allergies, such as itching., Horses environments are full of substances that can trigger the immune system and cause allergies. Apoquel doses are usually between .04-.06 milligrams per kilogram of body weight (mg/kg) . 8. 16. and unfortunately grass and dust are the main culprits. Since oclacitinib has been shown to be comparable to prednisolone, oclacitinib can be a good alternative to prednisolone when combined with cyclosporine for initial treatment. Treatment should be started at a dose of 0.4 - 0.6 mg per kilogram bodyweight twice a day for up to two weeks. Yes, we looked into this approach, but unfortunately it was not a viable option for my horse for a variety of reasons including other health factors and severity of allergies. Cosgrove SB, Cleaver DM, King VL, et al. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. Apoquel For Cats: Dosage, Safety & Side Effects - Cats.com Despite its delayed effects, cyclosporine is still a popular drug to treat canine atopic dermatitis because in some cases it can be dosed every other day or even every third day after initial daily treatment. Some dogs exhibit increased pruritus when the dosage is reduced to once daily. Apoquel Dosing & Administration - Apoquel (oclacitinib tablet) I Have you considered trying allergy testing? These animals require the opposite regimen. Apoquel delivers onset of relief within 4 hours and effectively controls itching within 24 hours. Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. Clenbuterol dilates the airways, and may improve air flow, but it doesn't treat the inflammation associated with the disease. Sometimes it goes overboard and reacts in the face of a generally harmless substancewhich the body begins to recognize as an allergenand an allergic reaction occurs. In many cases, symptomatic therapy alone with drugs such as oclacitinib is insufficient to control allergies long-term. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. Apoquel reduces dog itch, and also decreases inflammation, redness, or swelling of the skinso your dog feels better as quickly as possible What is Apoquel Tablet? Stay current with the latest techniques and information sign up below to start your FREE Todays Veterinary Practice subscription today. We have had variable results with this treatmet. Even though the drug is currently labeled for use in dogs (with allergic dermatitis), initial studies show that horses absorb it well, Fultz says. I have noticed that in general she is more comfortable on cooler days. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Cosgrove SB, Wren JA, Cleaver DM, et al. The only FDA-approved equine PSGAG. | Adequan i.m. See full Excede for Swine Prescribing Information. But it will take me through a month if I stay at every other after the loading. For atopic and allergic dermatitis, Apoquel may be given to dogs at a dosage of 0.18 - 0.27 mg/lb. Successful treatment of atopic dermatitis with the JAK1 inhibitor oclacitinib. Vet Dermatol 2017;28(5):485-e113. Levy BJ, Linder KE, Olivry T. The role of oclacitinib in the management of ischaemic dermatopathy in four dogs. Apoquel | European Medicines Agency Simpson AC, Schissler JR, Rosychuk RAW, et al. Nevertheless, these data should be taken with caution, and only as an approximation, because there is no basic information on the . to 14 days, and then administered once daily for maintenance therapy. Apoquel is the #1 prescribed medicine for fast, effective relief of allergic itch and inflammation due to atopic and allergic dermatitis 1 Indications Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.